Nucleic acid structure and synthesis (Parish, J.H.)
نویسندگان
چکیده
منابع مشابه
Nucleic Acid Synthesis
INTRODUCTION Synthesis in the field of nucleic acids has been a major and continuing interest in my laboratory ever since we knew the structures of the nucleic acids. Clearly the foundations of synthetic work in the nucleotide field were laid by the prolonged and intensive efforts of Professor Todd's laboratory (Cambridge, England) and it was my good fortune to be associated with this laborator...
متن کاملOrganometallic methodologies for nucleic acid synthesis
A new, general preparation of 2'-5'-linked oligoadenylates has been developed, which relies on: (1) chemoselective 0phosphorylation of N-unblocked nucleosides via hydroxyl activation by Grignard reagents, (2) one-pot construction of internucleotide linkage using bifunctional phosphorylating agents, and (3) selective production of a 3',5'-di-O-protected adenosine. This solution-phase synthesis a...
متن کاملStructural Biochemistry/Nucleic Acid/DNA/DNA structure
Deoxyribonucleic acid (DNA) stores information for the synthesis of specific proteins. DNA has deoxyribose as its sugar. DNA consists of a phosphate group, a sugar, and a nitrogenous base. The structure of DNA is a helical, double-stranded macromolecule with bases projecting into the interior of the molecule. These two strands are always complementary in sequence. One strand serves as a templat...
متن کاملThe Structure of Yeast Nucleic Acid
The tetranucleotide theory of the structure of yeast nucleic acid was first enunciated by the writer1 and was subsequently conclusively demonstrated by the experimental evidence furnished by Levene and Jacobs,2 ‘and by Levene and La Forge.3 The facts on which the theory was based were: first, the isolation of four nucleosides; second, the isolation of simple pyrimidine nucleotides. These were o...
متن کاملA structure for deoxyribose nucleic acid.
A structure for nucleic acid has already been proposed by Pauling and Corey (1). They kindly made their manuscript available to us in advance of publication. Their model consists of three intertwined chains, with the phosphates near the fibre axis, and the bases on the outside. In our opinion, this structure is unsatisfactory for two reasons: (1) We believe that the material which gives the X-r...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Chemical Education
سال: 1988
ISSN: 0021-9584,1938-1328
DOI: 10.1021/ed065pa298